The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
نویسندگان
چکیده
منابع مشابه
The histone chaperones Vps75 and Nap1 form ring-like, tetrameric structures in solution
NAP-1 fold histone chaperones play an important role in escorting histones to and from sites of nucleosome assembly and disassembly. The two NAP-1 fold histone chaperones in budding yeast, Vps75 and Nap1, have previously been crystalized in a characteristic homodimeric conformation. In this study, a combination of small angle X-ray scattering, multi angle light scattering and pulsed electron-el...
متن کاملThe Histone Chaperones Nap1 and Vps75 Bind Histones H3 and H4 in a Tetrameric Conformation
Histone chaperones physically interact with histones to direct proper assembly and disassembly of nucleosomes regulating diverse nuclear processes such as DNA replication, promoter remodeling, transcription elongation, DNA damage, and histone variant exchange. Currently, the best-characterized chaperone-histone interaction is that between the ubiquitous chaperone Asf1 and a dimer of H3 and H4. ...
متن کاملNAP1 family histone chaperones are required for somatic homologous recombination in Arabidopsis.
Homologous recombination (HR) is essential for maintaining genome integrity and variability. To orchestrate HR in the context of chromatin is a challenge, both in terms of DNA accessibility and restoration of chromatin organization after DNA repair. Histone chaperones function in nucleosome assembly/disassembly and could play a role in HR. Here, we show that the NUCLEOSOME ASSEMBLY PROTEIN1 (NA...
متن کاملStructure of Vps75 and implications for histone chaperone function.
The vacuolar protein sorting 75 (Vps75) histone chaperone participates in chromatin assembly and disassembly at both active and inactive genes through the preferential binding to histone H3-H4. Vps75 is also one of two histone chaperones, along with antisilencing factor 1, that promotes histone H3-Lys-56 acetylation by the regulation of Ty1 transposition protein 109 (Rtt109) histone acetyltrans...
متن کاملEffect Algebras and Ring-like Structures
The dichotomic physical quantities, also called propositions, can be naturally associated to maps of the set of states into the real interval [0,1]. We show that the structure of effect algebra associated to such maps can be represented by quasiring structures, which are a generalization of Boolean rings, in such a way that the ring operation of addition can be non-associative and the ring mult...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2014
ISSN: 1362-4962,0305-1048
DOI: 10.1093/nar/gku232